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《Anhui Medical and Pharmaceutical Journal》 2010-05
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Bioavailability and bioequivalence of nimodipine capsules

GUO Zhong-jian1,TAO Chun-lei2,XU Fan2(1.Zhejiang Yadong Pharmacentical CO.,Ltd,Zhuji,Zhejiang 311800;2.Anhui College of TCM,Hefei,Anhui 230031)  
Aim To evaluate the bioavailability and bioequivalence of nimodipine capsules in healthy volunteers.Methods Single oral dose of 60 mg nimodipine capsules or reference drug was given to 20 volunteers in an open randomized cross way to study the relative bioavailability.The plasma concentrations were determined by LC-MS/MS.Results The pharmacokinetic parameters of test preparation and reference preparation were as flollows:Cmax :(37.459±13.224)μg·L-1 and(46.223±22.980)μg·L-1;Tmax:(1.150±0.384)h and(1.025±0.353)h;AUC(0~12):(94.721±27.457)μg·h-1·L-1and(95.755±32.246)μg·h-1·L-1;T1/2:(3.073±0.941)h and(3.026±1.139)h.Conclusion Statistic analysis shows that the two preparations were bioequivalent.
【Key Words】: nimodipine bioequivalent LC-MS/MS
【CateGory Index】: R969
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【Citations】
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