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《Journal of Anhui Traditional Chinese Medical College》 2001-01
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EFFECT OF ZISHEN HUOXUE JIEDU RECIPE ON mRNA EXPRESSION OF ET-1 IN REMNANT KIDNEY OF RATS WITH CHRONIC RENAL FAILURE

MA Jian-wei,CAI Qing,LIU Zhan-min,XU Li-mei, CHEN Bao,WEI Han-lin,HOU Jie,DONG Jing (General Hospital of Air force,PLA,Beijing 100036,China)  
Objective:To explore effects of Zishen Huoxue Jiedu recipe(ZSHXJDR) on the mRNA expression of endothelin-1(ET-1)in remnant kidney of rats with chronic renal failure(CRF).Method:Rats were divided into five groups:ZSHXJDR group,lotensin group,Baoshenkang group(BSK),control group,normal control group.CRF animal model of rats were established after 5/6 of kidney mass were removed.The mRNA expression levels of ET-1 in remnant kidney were measured by semi-quantitative reverse transcription polymerase chain reaction(RT-PCR)。Result:The ET-1 mRNA expression levels in remnant kidney of control group was significantly higher than that of normal control group,ZSHXJDR group,lotensin group,and BSK group.The ET-1 mRNA expression levels in remnant kidney of ZSHXJDR was significantly lower than that of lotensin group,BSK group.Conclusion:ZSHXJDR can markedly improved renal function by down-regulating ET-1mRNA expression levels,reducing glomerular sclerosis.
【CateGory Index】: R285.5
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