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《Journal of Anhui Traditional Chinese Medical College》 2001-01
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STUDY ON GYPENOSIDES INHIBITING NEOPLASM GROWTH AND ELEVATING IMMUNOLOGICAL FUNCTION IN LEWIS LUNG CANCER OF MICE

LIU Xia,WANG Ping-jun,Xu Fu-xin (The Frist People's Hospital of Wuhu,Anhui Wuhu 241000,China)  
Objective:To study the effects of Gypenosides(GPs) on neoplasm growth,total number of splenic cells and NK cell activity.Method:Anti-tumor experiment in mice was carried out and the total number of splenic cells and NK cell activity were determined.Result:GPs could significantly inhibit the growth of Lewis lung cancer in mice.The tumor weight inhibiting(TWI)rates was (29.8±1.3)%,(51.4±2.2)% and (50.0±1.6)% after ip GPs 10,20 and 40mg/kg,respectively.The total number of splenic cells and the NK cell activity of both peripheral blood lymphocyte(PBL) and splenic cells were elevated.Conclusion:The anti-tumor effect of GPs is related to the elevated immunological function of tumor-grafted mice.
【CateGory Index】: R273
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