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《Journal of Anhui Traditional Chinese Medical College》 2003-01
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Effect of Electro-acupuncture Preconditioning on Free Radical Content in Brain of Rats with Cerebral Ischemia Reperfusion

GUO Jia, WANG Lei, ZHANG Li, YUAN Hong (Department of Traditional Chinese Medicine,the Third Hospital, Beijing University, Beijing 100083, China)  
Objective:To study the effect of electro acupuncture preconditioning on contents of Glutathione (GSH),Malonyldialdehyde (MDA) in the brain of rats with cerebral ischemia reperfusion. Method: The rat model of middle cerebral artery occlusion (MACO) was established by using intraluminal thread. The contents of MDA, GSH in the brain of the rats after 2 hours cerebral ischemia followed by 24 hours reperfusion were observed. Result: In electro acupuncture preconditioning group, the MDA level in brain tissue was significantly decreased (P0.01), while GSH level in the rat brains showed an increment tendency compared to the model group. Conclusion: Electro acupuncture preconditioning can inhibit the growth of free radicals and promote the activity of scavenger enzyme of free radicals so as to reduce the damage and protect neurons of rats undergone cerebral ischemia reperfusion injury.
【Fund】: 国家中医药管理局课题 (2 0 0 0 J P 6 3)
【CateGory Index】: R245.97
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