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《Journal of Anhui Traditional Chinese Medical College》 2003-01
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Study on Treatment of Gushen Capsule for Experimental Diabetic Nephropathy in Rats

ZHOU Dong zhi, SU Ke liang, WANG Ling ling, WU Su dong, WANG Jin yuan (Department of Traditional Chinese Medicine, the First Hospital, Xi′an Jiaotong University, Shaanxi Xi′an 710061,China)  
Objective:To observe the therapeutic effects of Gushen capsule on diabetic nephropathy(DN) in rats. Method: After resection of one kidney and injection of streptozotocin (STZ), the DN rat model was established. Rats were randomly divided into 4 groups. Group 1 was model group, Group 2 was given kaibotong and diamicron by gastrogavage, Group 3 was given large dosage of Gushen capsule, Group 4 was given small dosage of Gushen capsule. After 8 weeks of administration, the weight of rat kidney, renal function and the excretion of urine albumin were measured. Result: The weight of kidney, weight of kidney/body weight ratio, blood urea nitrogen, creatinine and the excretion of urine albumin of Gushen capsule treated groups had a lower level than those of model group significantly. There was no significant difference between Gushen capsule treated groups and Group 2. Conclusion: Gushen capsule can not only inhibit the hypertrophy of kidney, but also improve renal function and reduce urine albumin.
【Fund】: 陕西省中医药管理局基金资助 (980 0 9)
【CateGory Index】: R285.5
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