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《Journal of Anhui Traditional Chinese Medical College》 2003-01
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Protective Effect of Breviscapine Dropping Pill Against Focal Cerebral Ischemia Reperfusion Injury in Rats

ZHANG Xiao bing, PENG Dai yin, ZHU Man fang,ZHOU Ya Qiu, LIU Qing yun (Department of Pharmacy, Anhui College of Traditional Chinese Medicine,Anhui Hefei 230038,China)  
Objective:To investigate the protective effect of breviscapine dropping pill against brain injury in rats undergone focal ischemia reperfusion. Method: Wistar rats were treated with breviscapine dropping pill for 7 days and were subjected to focal ischemia by middle cerebral artery occlusion(MCAO) using intraluminal thread. After 2 hours of MCAO reperfusion was allowed by retracting the thread. The nerve symptoms were observed after 1 hour of reperfusion and the infarcted area, the level of malonyldialdehyde(MDA), the activity of superoxide dismutase(SOD) and glutathione peroxidase (GSH Px) in ischemic brain tissue were observed after 24 hours. Result: Breviscapine dropping pill of different dose all could improve behavior disorder induced by MCAO and reduce brain infarcted area through increasing the activity of SOD and GSH Px and decreasing the level of MDA in brain tissue. Conclusion: Breviscapine dropping pill has protective effect against focal brain damage induced by occlusion reperfusion in middle cerebral artery of rats.
【CateGory Index】: R285.5
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