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《Journal of Anhui Traditional Chinese Medical College》 2003-05
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Research on Relativity between Hemorrheology Indexes and the Levels of Endothelin and Thromboxane B_2 in Rats with Lung Qi Deficiency Syndrome

CAI Sheng rong,FANG Zhi bin,HUANG Kai quan,WANG Yuan xun (Department of Integrated Traditional and Western Medicine, Anhui College of Traditional Chinese Medicine, Anhui Heifei 230038, China)  
Objective:To study the relativity between hemorrheology indexes and the levels of thromboxane B 2(TXB 2) and endothelin(ET) in rats with lung Qi deficiency syndrome.Method:Sixty rats were randomly divided into model group and control group.Hemorrheology indexes and the levels of TXB 2 and ET were determined.Result: In model group, the whole blood viscidity ,plasma viscidity, hematocrit, erythrocyte aggregation index and fibrinogen all increased in comparison with those of control group (P0.01 or P0.05),while the levels of ET and TXB 2 increased significantly (P0.01 ).The whole blood viscidity was positively related to ET and TXB 2 separately(r=0.957,P0.05;r=0.992,P0.01 ).Conclusion: Lung Qi deficiency syndrome has the phenomena of blood stasis,and the levels of ET and TXB 2 in plasma tends to increase with lung Qi deficiency syndrome aggravating gradually.
【Fund】: 安徽省自然科学基金项目 (0 0 0 4 4 118)
【CateGory Index】: R256.1
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