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《Journal of Anhui Traditional Chinese Medical College》 2003-05
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Experimental Research on Effect of Guava Leaf in Treating the Human Rotavirus Enteritis

ZHAO Yun yan,XIE Wei,CHEN Bao tian,YANG Jie,XIAO Bin (Guangzhou Hospital of Traditional Chinese Medicine,Guangdong Guangzhou 510130,China)  
Objective:To observe the effect of Guava Leaf in treating the human rotavirus(HRV) enteritis in mice and explore its mechanism.Method: One hundred and twenty BLAB/C mice were randomly divided into six groups: normal control group, infected control group, Huoxiang Zhengqi Oral Liquid group, high, moderate and low dosage of Guava Leaf groups. Animal model was set up according to Schonb′s method. After 24 hours,normal and infected control groups were given normal saline; Huoxiang Zhengqi Oral Liquid(1.62 g/kg) group and high(3.6 g/kg), moderate(1.8 g/kg) and low(0.9 g/kg)dosage of Guava Leaf groups were administered by intragastric injection 3 times daily, and 20 ml/kg every time.The period of treatment was 72 hours.the fata lity rate,pathologic changes in mucous membrane of the small intestine,biochemical changes in blood and feces, the content of SIgA in feces and the percentage of the changes of HRV from the positive to the negative were observed. Result: There was a significant difference between the high, moderate dosage of Guava Leaf groups and Huoxiang Zhengqi Oral Liquid group,low dosage of Guava Leaf group in the fatality rate, pathologic changes in mucous membrane of the small intestine,biochemical changes in blood and feces,the content of SIgA ,Na + and sugar in feces, the packed cell volume in blood, the percentage of the changes of HRV from the positive to the negative(P0.05). Conclusion: Guava Leaf is effective in treating the HRV enteritis and its mechanism might be related to increasing the content of SIgA in feces, promoting the repair of mucous membrane of the small intestine, increasing the absorbtion of Na + and sugar and alleviating the dehydration as well as improving the percentage of the changes of HRV from the positive to the negative.
【Fund】: 广东省中医药管理局科学基金项目 (996 85 )
【CateGory Index】: R259.7
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