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《Journal of Anhui Traditional Chinese Medical College》 2006-01
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Content Determination of Dextroisomer in Levobupivacaine Hydrochloride by HPLC

DONG Zhen-xiu,WANG Yun,XU Yan,ZHU Sheng-liang,SUN Bao-xiang(Jiangsu Hengrui Medicine Co.Ltd.,Jiangsu Lianyungang 222002,China)  
Objective: To establish a HPLC method for the determination of dextroisomer in levobupivacaine hydrochloride.Method: A chiral chromatographic column(CHROMTECH AGP 100.0 mm×4.0 mm,5 μm) was employed with 0.02 mol/L phosphate buffer-isopropanol(90∶10) as mobile phase.The detection wavelength was 215 nm.Result: The dextroisomer in levobupivacaine hydrochloride can be resolved.The detectability and isolation quantitation limit of levobupivacaine hydrochloride was 0.6 ng and 2 ng.Conclusion: HPLC method can be used for the resolution and determination of dextroisomer in levobupivacaine hydrochloride raw material and its injection.
【CateGory Index】: R927
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