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《Journal of Anhui Traditional Chinese Medical College》 2006-01
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Content Determination of Dextroisomer in Levobupivacaine Hydrochloride by HPLC

DONG Zhen-xiu,WANG Yun,XU Yan,ZHU Sheng-liang,SUN Bao-xiang(Jiangsu Hengrui Medicine Co.Ltd.,Jiangsu Lianyungang 222002,China)  
Objective: To establish a HPLC method for the determination of dextroisomer in levobupivacaine hydrochloride.Method: A chiral chromatographic column(CHROMTECH AGP 100.0 mm×4.0 mm,5 μm) was employed with 0.02 mol/L phosphate buffer-isopropanol(90∶10) as mobile phase.The detection wavelength was 215 nm.Result: The dextroisomer in levobupivacaine hydrochloride can be resolved.The detectability and isolation quantitation limit of levobupivacaine hydrochloride was 0.6 ng and 2 ng.Conclusion: HPLC method can be used for the resolution and determination of dextroisomer in levobupivacaine hydrochloride raw material and its injection.
【CateGory Index】: R927
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【References】
Chinese Journal Full-text Database 1 Hits
1 Yu Ting,Cai Tong and Zhang Guolai(National Institute for the Control of Pharmaceutical and Biological Products,Beijing 100050);The Study for Bacteria Eendotoxin Test of Bupivacaine Hydrochloride Injection[J];Chinese Pharmaceutical Affairs;2009-08
【Co-references】
Chinese Journal Full-text Database 8 Hits
1 LI Hong-qing,ZHANG Xiao-jia,WU Li-juan(The Second People's Hospital of Shantou City,Guangdong Shantou 515011,China);The Clinical Comparison of Ropivacaine Hydrochloride and Bupivacaine Hydrochloride Used in the Elevation Epidural Anesthesia[J];Hebei Medicine;2009-01
2 CHEN Yan-hua,DIAO Yu-hui (The Affiliated Drum Tower Hospital of Nanjing University,Nanjing 210008,China);The application of Bacterial endotoxin tests in the pyrogen quality control of injections[J];West China Journal of Pharmaceutical Sciences;2004-05
3 SONG Jundo-ng Department of Aneshesiology Hailar Railway Central Hospital in Neimengu , Hailar 021000;A Comparison of Ropivacaine and Racemic Bupivacaine for Postoperative Epidural Analgesia[J];Chinese Journal of Clinical Medicine;2007-02
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