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《Journal of Anhui Traditional Chinese Medical College》 2013-01
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Effects of Granules for Tonifying Kidney and Preventing Miscarriage on Serum Levels of Vascular Endothelial Growth Factor and Soluble Fms-like Tyrosine Kinase-1 in Patients with Recurrent Spontaneous Abortion

LI Wei-li,HU Rui-hua(Department of Gynecology,The First Hospital Affiliated to Anhui College of Traditional Chinese Medicine,Anhui Hefei 230031,China)  
Objective To investigate the mechanism by which Granules for tonifying the kidney and preventing miscarriage exert therapeutic effect in patients with recurrent spontaneous abortion(RSA).Methods Thirty RSA patients(as treatment group) and 30 women with normal early pregnancy(as control group) were included in this study.Enzyme-linked immunosorbent assay(ELISA) was used to measure the serum levels of vascular endothelial growth factor(VEGF) and soluble fms-like tyrosine kinase-1(sFlt-1) before and after treatment with the granules for tonifying the kidney and preventing miscarriage.ResultsThe success rate of pregnancy was 80.00% in the treatment group.Before treatment,the treatment group had significantly lower serum VEGF level and significantly higher serum sFlt-1 level than the control group(P0.01 for both comparisons).The treatment led to significantly increased serum VEGF level and significantly decreased serum sFlt-1 level in the treatment group(P0.01 for both comparisons).Compared with those successfully treated with the granules,the patients without response to the treatment had significantly lower serum VEGF level(P0.01) and significantly higher serum sFlt-1 level(P0.05).ConclusionThe granules for tonifying the kidney and preventing miscarriage can be used for treating RSA,which may be related to their ability to increase serum VEGF level and decrease serum sFlt-1 level,thus promoting the formation of placental villous vessels.
【Fund】: 安徽省卫生厅中医药科研课题(2012ZY14)
【CateGory Index】: R271.9
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【Citations】
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【Co-citations】
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