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《Journal of Anhui Traditional Chinese Medical College》 2013-01
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Effects of Traditional Chinese Medicine Formula for Nourishing Kidney-Essence on Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells in Rabbits in Different Phases of Fracture Healing

WANG Bin,LUO Yi-wen,HU Nian-hong(Affiliated Orthopaedic Hospital of Guangzhou University of Traditional Chinese Medicine,Guangdong Guangzhou 510240,China)  
Objective To observe the effects of traditional Chinese medicine(TCM) formula for nourishing kidney-essence on the osteogenic differentiation of bone marrow mesenchymal stem cells(BMSCs) in rabbits in different phases of fracture healing.Methods Twenty white rabbits were divided into normal control group,fracture model group,TCM treatment group,and Western medicine(WM) treatment group.The BMSCs at the fracture ends were isolated and cultured,and the passage 3 cells were collected and then induced to differentiate into osteoblasts.Alkaline phosphatase(ALP) assay kit and osteocalcin(OCN) assay kit were used to measure the ALP activity and OCN level,respectively.Results After fracture,the ALP activity and OCN level increased gradually in the fracture model group,TCM treatment group,and WM treatment group.At 14 and 21 days after fracture,the TCM treatment group had significantly higher ALP activity and OCN level than the other three groups(P0.05 or P0.01).Conclusion TCM formula for nourishing kidney-essence can promote the osteogenic differentiation of BMSCs in rabbits in different phases of fracture healing.
【Fund】: 广东省社会发展科技计划项目(20100308)
【CateGory Index】: R274
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