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Effects of Yanghe Pingchuan Granule on Serum Levels of Matrix Metallopeptidase-2 and Matrix Metallopeptidase-9 and Airway Inflammation in Rats with Chronic Asthma

ZHU Shun-zhi;ZHU Hui-zhi;LONG Zheng-yin;WANG Da-wei;ZHANG Qiu-ping;LIU Lu;Graduate Division,Anhui University of Chinese Medicine;Department of Respiratory Medicine,The First Affiliated Hospital of Anhui University of Chinese Medicine;Tongling Hospital of Traditional Chinese Medicine;  
Objective To study the effects of Yanghe Pingchuan Granule on serum levels of matrix metalloproteinase-2(MMP-2)and matrix metalloproteinase-9(MMP-9)and airway inflammation in rats with chronic asthma.Methods Fifty clean Sprague-Dawley rats were randomly divided into normal group,model group,low-and high-dose Yanghe Pingchuan Granule groups,and dexamethasone group.Ovalbumin was adopted to establish a rat model of asthma.The normal and model groups were given normal saline instead of Yanghe Pingchuan Granule or dexamethasone.After hematoxylin and eosin staining,the pathomorphological changes of lung issues were observed,and various inflammatory cells in the bronchoalveolar lavage fluid were counted under a light microscope.The serum levels of MMP-2and MMP-9were measured by enzyme-linked immunosorbent assay.Results The low-and high-dose Yanghe Pingchuan Granule groups and dexamethasone group had decreased infiltration of inflammatory cells in the airway wall mucosa and surrounding lung tissue and significantly reduced airway epithelial cell hyperplasia compared with the model group.Compared with the model group,the high-dose Yanghe Pingchuan Granule group and dexamethasone group had significantly reduced total cell count and counts of various inflammatory cells in bronchoalveolar lavage fluid and serum levels of MMP-2and MMP-9(P0.05),while the low-dose Yanghe Pingchuan Granule group showed no significant changes in total cell count and counts of various inflammatory cells in bronchoalveolar lavage fluid and serum level of MMP-2(P0.05).Conclusion The performance of Yanghe Pingchuan Granule in suppressing airway inflammation may be related to its function of reducing serum levels of MMP-2and MMP-9.
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