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Optimization of Extraction and Isolation of Morellic Acid in Garciniahanburyi and Its Structure Confirmation

JIABu yun;PENG Dai-yin;LI Shan-shan;HU Xue-rui;ZHU Guang-yu;CHEN Wei-dong;School of Pharmacy,Anhui University of Chinese Medicine;Ma'anshan Central Hospital;  
Objective To establish an efficient and repeatable method for isolation of morellic acid and to confirm the structure of isolated product.Methods Garcinia hanburyi was subjected to ethanol ultrasonic extraction,and the ethanol extract was treated by a combination of medium-pressure preparative chromatography and high-pressure preparative chromatography to isolate and purify morellic acid.An orthogonal design was used to optimize the extraction and isolation process.Also,infrared spectrometry,mass spectrometry,1 H-nuclear magnetic resonance(NMR),and 13C-NMR were used for the structural identification of isolated sample.Results The optimized isolation method was simple and controllable.The isolated sample was structurally identified as morellic acid with a purity over 99%.Conclusion The established extraction and isolation method for morellic acid is efficient,simple,and repeatable.This study also provides relatively full spectral information on morellic acid and confirms the structure of isolated morellic acid.
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