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《Journal of Anhui University of Chinese Medicine》 2017-04
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Clinical Effect of Tongmai Decoction in Preventing Deep Vein Thrombosis in High-risk Population in the Perioperative Period

ZENG Yan-hui;LIANG Wei-chun;Department of Orthopedics,Foshan Hospital of Traditional Chinese Medicine;  
Objective To investigate the clinical effect of Tongmai Decoction in preventing deep vein thrombosis(DVT)in high-risk population in the perioperative period after trauma.Methods A total of 90 patients with closed comminuted femoral fracture at a high risk of DVT were enrolled,and according to the treatment regimen,these patients were divided into groupsⅠ(Sanqi Pill+Tongmai Decoction),Ⅱ(Sanqi Pill+Fraxiparine),and Ⅲ(Sanqi Pill+Fraxiparine+Tongmai Decoction),with 30 patients in each group.The clinical outcome,changes in coagulation factors,and incidence rate of DVT were observed in all groups.Results All patients achieved good clinical outcomes after treatment,but there was no significant difference in clinical outcome between the three groups(P0.05).All the three groups had significant changes in coagulation factors at 2and 6days after surgery(P0.05),except D-dimer(D-D)and platelet count(PLC)for groupⅡat 2days.D-D,PLC,antithrombinⅢ(AT-Ⅲ),fibrinogen(Fbg),and coagulation factorⅧ(FⅧ)showed certain changes from 2to 6days after surgery,and most of them had significant changes(P0.05).Compared with group Ⅱ,groupsⅠ and Ⅲ had significantly greater improvements in coagulation factors at 2and 6days after surgery.There was no significant difference in the incidence rate of DVT between the three groups(P0.05).Conclusion Sanqi Pill+Tongmai Decoction,Sanqi Pill+Fraxiparine,and Sanqi Pill+Fraxiparine+Tongmai Decoction have marked clinical effects and can effectively improve the levels of coagulation factors D-D,PLC,AT-Ⅲ,Fbg,and FⅧin high-risk population and prevent DVT in the perioperative period.
【Fund】: 佛山市医学类科技攻关项目(2014AB00323)
【CateGory Index】: R274.9
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