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《Journal of Anhui University of Chinese Medicine》 2017-04
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Regulatory Effect of Guanxinping on Vascular Endothelial Dysfunction in Patients with Angina Pectoris

ZHANGHong bing;YUAN Li-hong;Nanjing University of Chinese Medicine;Department of Cardiology,Jiangsu Provincial Hospital of Traditional Chinese Medicine;  
Objective To investigate the effect of the compound preparation Guanxinping in improving vascular endothelial function in patients with angina pectoris.Methods A total of 80 patients with angina pectoris were randomly divided into experimental group and control group,with 40 patients in each group.The patients in the experimental group were given Guanxinping in addition to routine drug treatment,and those in the control group were given Xinkeshu in addition to routine drug treatment.The course of treatment was 4weeks for both groups.The clinical outcome was observed in both groups,and the serum levels of nitric oxide(NO),endothelin-1(ET-1),thromboxane B2(TXB2),and 6-ketone prostaglandin F1alpha(6-keto-PGF1α)were compared before treatment and after 4weeks of treatment.Results There was a significant difference in the distribution of clinical outcomes between the two groups(P0.05).After treatment,the experimental group had significant increases in NO and 6-keto-PGF1αand significant reductions in ET-1and TXB2(P0.05);the control group also had significant increases in NO and 6-ketoPGF1α(P0.05)and reductions in ET-1and TXB2(P0.05).The experimental group had significantly better improvements in these indices compared with the control group(P0.05).Conclusion Guanxinping can act on vascular endothelial function through various targets,which may be one of its mechanisms of action in the prevention and treatment of coronary heart disease.
【Fund】: 国家教育部博士点基金课题(20093237110001)
【CateGory Index】: R541.4
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