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《Journal of Anhui University of Chinese Medicine》 2017-04
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Effects of Yanghe Pingchuan Granule Given Early or Late on Interleukin-5 and Interleukin-9 in Bronchoalveolar Lavage Fluid in Rats with Asthma

YAO Huan;LIU Lu;ZHU Hui-zhi;LIU Xiang-guo;WANG Yong-zhong;Graduate Division,Anhui University of Chinese Medicine;Department of Respiratory Medicine,The First Affiliated Hospital of Anhui University of Chinese Medicine;  
Objective To investigate the mechanism of action of Yanghe Pingchuan Granule in preventing and treating bronchial asthma by measuring the levels of cytokines.Methods Eighty-four clean SpragueDawley rats were randomly divided into normal group,model group,dexamethasone group,early intervention with low-dose Yanghe Pingchuan Granule group,early intervention with high-dose Yanghe Pingchuan Granule group,late intervention with low-dose Yanghe Pingchuan Granule group,and late intervention with high-dose Yanghe Pingchuan Granule group.A rat model of asthma was established by long-term sensitization and challenge with ovalbumin.These rats received respective treatments.The pathological changes of lung tissues were evaluated.ELISA was used to measure the levels of interleukin-5(IL-5)and interleukin-9(IL-9)in bronchoalveolar lavage fluid(BALF).Results Compared with the model group,all treated groups had reduced inflammatory cell infiltration in the tracheal mucosa and vascular tissues around the lungs and reduced tracheal wall thickening.Early intervention with Yanghe Pingchuan Granule was superior to late intervention with Yanghe Pingchuan Granule in reducing IL-5and IL-9in BALF,and high-dose Yanghe Pingchuan Granule was superior to low-dose Yanghe Pingchuan Granule in reducing IL-5and IL-9in BALF.Late intervention with low-dose Yanghe Pingchuan Granule is comparable to dexamethasone in reducing IL-5and IL-9in BALF.Conclusion Yanghe Pingchuan Granule can be used for preventing and treating bronchial asthma,and its mechanism of action involves reducing IL-5and IL-9in BALF.Yanghe Pingchuan Granule is more effective if given earlier,and it acts in a dose-dependent manner.
【Key Words】: Asthma Yanghe Pingchuan Granule Interleukin-5 Interleukin-9
【Fund】: 国家自然科学基金项目(81373600);; 安徽省教育厅重点项目(KJ2013A174)
【CateGory Index】: R285.5
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