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《Journal of Anhui University of Chinese Medicine》 2017-04
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Cardioprotective Effect of Xiwang Ⅱ in Mice Exposed to Passive Smoking

ZHANG Rui;PENG Jin-e;WANG Xiang;FENG Xuan-ye;LIU Lin-lin;DAI Ning;FENG Li-li;SUN Yan;ZHAO Xin;CAI Da-yong;WANG Yue-qi;School of Traditional Chinese Medicine,Beijing University of Chinese Medicine;Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences;  
Objective To investigate the cardioprotective effect of Xiwang Ⅱin mice exposed to passive smoking and its mechanism of action.Methods A total of 72 male Kunming mice were randomly divided into control group,model group,positive drug group,and low-,middle-,and high-dose Xiwang Ⅱgroups.The mice in the control group were exposed to laboratory air,and those in the model group were exposed to cigarette smoke for 45 consecutive days(3hours a day).The drugs were administered since day16 of exposure and the mice were sacrificed on day 45 to collect heart tissue.The level of malondialdehyde(MDA)in the heart was measured,as well as the activities of cardiac total superoxide dismutase(T-SOD),copperzinc superoxide dismutase(Cu-ZnSOD),and myeloperoxidase(MPO).The histomorphological features of the heart were observed and the collagen fiber area in the heart was calculated.Immunohistochemistry was used to measure the expression of transforming growth factor-β1(TGF-β1)in the heart.Results Compared withthe control group,the model group had significant reductions in the activity of Cu-ZnSOD and T-SOD(P0.05)and significant increases in MPO activity,MDA level,cardiac muscle fibers,and TGF-β1expression(all P0.05).Compared with the model group,the low-,middle-,and high-dose XiwangⅡ groups had significant increases in the activities of Cu-ZnSOD and T-SOD(P0.05)and significant reductions in MPO activity,MDA level,cardiac muscle fibers,and TGF-β1expression(all P0.05).Conclusion Xiwang Ⅱ exerts its cardioprotective effect on mice exposed to passive smoking by regulating oxidative stress response in the heart.
【Key Words】: Xiwang Ⅱ Passive smoking Myocardial damage Antioxidant enzyme Oxidative stress response Transforming growth factor-β1
【Fund】: 北京中医药大学创新团队项目(2011-CXTD-04)
【CateGory Index】: R285.5
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