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《Amino Acids & Biotic Resources》 2010-03
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Effect of Deuterium-Depleted Water on Immunomodulation in Mice

LIAN Lu1,CONG Feng-song2,CAI Dong-lian1,LIN Ning1,QU Dan1,ZHENG Hui1,WANG Jie1(1、Department of Clinical Nutrition,Changhai Hospital,Second Military Medical University,Shanghai 200433;2、College of Life Science And Technology,Shanghai Jiao Tong University,Shanghai 200240,China)  
To evaluate the immunomodulating effects of deuterium-depleted water(DDW) on normal mice,all of the mice were divided into 2 groups.One was the experimental group accepted DDW as the water,and another was the control group.After 6 weeks,IgG,IgM,thymus index,spleen index,the proliferation of spleen lymphocytes,the activity of NK cell,CD4+,CD4+/CD8+ and dinitrofluorobenzeneinduced delayed type hypersensitivity test(DTH) were employed to evaluate the immunomodulating effects of DDW on non-specific and specific immunologic function of normal mice.DDW increased the level of IgM,spleen index,CD4+ and CD4+/CD8+.DDW improved non-specific and specific immunologic function of normal mice.
【CateGory Index】: R151
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