In Vitro Experiment on Inhibition of Tea Polyphenol Isolated from Green Tea on Growth of Human Cervical and Lung Cancer Cells
Zhang Guoying Li Yanyong Ding Zongyou (Anhui Asricultural College) Wu Yilun He Lina (Anhui Provincial Medicine Research Instiute)
The results obtained from our experiments show that the tea polyphenol isolated from green tea can inhibite the growth of both human cervical cancer cell line (Hela cell) and human lung cancer line (A—549), and that the inhibitory efficiency of tea polyphenol is better than that of methotrexate (MTX), the anticancer drug. The experiment reveals that the cells of human cervical and lung cancer were 50 and 55% injured when 500 ug of tea polyphenol was added to 1 ml cell culture solution, but the efficiency for MTX were 13 and 25%. However, the efficiency of tea polyphenol reduced with the decrease of the concentrations of the chemical component. The anticancer mechanism of tea polyphenol may be that tea polyphenol could result in a damage to cell membrance and produce effects on some metabolism in the cells.