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《Oncology Progress》 2009-06
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Effectiveness and safety of docetaxel combined with carboplatin in treating recurrent or metastatic breast cancer

Pan Jinhua Ding Tao Zhongxiang People's Hospitol of Hubei Province,Zhongxiang 431900,China  
Objective To explore the clinical effectiveness and safety of docetaxel combined with carboplatin(DC) in treating recurrent or metastatic breast cancer.Methods Totally 68 Patients with recurrent or metastatic breast cancer were randomly divided into DC group and control group.DC group was given docetaxel combined with carboplatin,while the contol group was given NVB combined with DDP. The clinical effectiveness and safety were evaluated.Results In DC group,the response rate was 46.9%and disease control rate of 71.9%;in the control group,the response rate was 41.9%and disease control rate was 68.8%(P0.05).In the DC group,the survival rate was 28.1%and the mortality rate was 71.9%;in the control group,the survival rate was 22.6%and the mortality rate was 77.4%(P0.05).Severe leukopenia and hair loss was noted in both two groups(90%).However, in the DC group,Ⅲ-Ⅳlevel toxic events were significantly less than in the control group(P0.05);also,gradeⅢ-Ⅳincidences of joint muscle pain,nausea and vomiting were significantly lower than in the control group(P0.05).Conclusion Docetaxel combined with carboplatin is effective in treatment of recurrent or metastatic breast cancer,and its adverse reactions are acceptable.
【CateGory Index】: R737.9
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