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《Oncology Progress》 2009-06
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Brain metastases after hepatocellular carcinoma:Clinical analysis of 8 cases

Wu Yanfang~1 Yang Boyan~1 Wang Jinwan~2 1 Department of Emergency Oncology,2 Department of Medical Oncology,Cancer Institute&Hospital, Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100021,China  
Objective To investigate the clinical characteristics and treatment methods of hepatocellular carcinoma(HCC) patients with intracranial metastasis.Methods From January 1994 to June 2008,8 HCC patients with intracranial metastasis were treated in our hospital.Clinical characteristics, treatment methods,and surrival time were analyzed retrospectively.Results Of the 8 patients,there were 7 males.The median age was 50.0 yeaes.Five patients have chronic hepatitis B and cirrhosis.Alpha fetoprotein1000ng/ml was noted in 7 patients;extraordinary high level(10000ng/ml) was also seen in 2 patients.Headache as the initial manifestation was common in our series(4/8).Hemiparesis, dizzy,or sensory disturbance was found in 3 cases,diplopia in 2 cases,conscious disturbance in 1 case and dysarthria in 1 case.Six patients had two or more symptoms.Five patients experienced pulmonary metastasis.Four patients died within two months.Conclusion The prognosis of HCC with intracranial metastasis is poor,and its treatment requires further research.
【CateGory Index】: R735.7
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