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《Oncology Progress》 2009-06
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Preliminary study of stereotactic radiotherapy for retinoblastoma

Song Yipeng~(1,2) Hu Likuan(?) Zhu Xinli~2 Wang Yunyan~2 Sun Zhenyuan~2 1 Department of Radiation Oncology,Yantai's Yuhuangding Hospital,Medical College of Qingdao University,Yantai 264000,China 2 Department of Radiation Oncology,Qilu Hospital,Medical College of Shandong University,Jinan 250000,China  
Objective To investigate the result of stereotactic radiotherapy(SRT) for retinoblastoma, a new approach of treatment with improvement of the tumor control and conservation of partial vision. Methods From July 2003 to July 2005,16 patients with retinoblastoma were treated with SRT,under the eyeball fixation,MVCCOP.Among them,2 patients with partial vision received only a single dose of 1900 and 2200cGy,respectively;the other 14 received FSRT,with 3600-4200 cGy/3-4fractions/14 -21days for 13 patients and 3000cGy/6 fractions/42days for 1 patient.The reference dose was defined with 90%-100%isodose covering the target in patients with 5-30mm collimater.Results The median follow-up was 15 months,ranging from 6 months to 23 months.The mean survival time was 10 months and the median survival time was 15 months.Fourteen patients survived while 2 died.In 10 patients, the tumor lesion shrank or disappeared and their eyeballs with partial vision were conserved.All patients were free from complications except for retina detachments in different degree.Conclusion SRT is a safe and effective treatment for retinoblastoma.It can control the disease and keep the involved eyeball and partial eyesight conserved in some patients.
【CateGory Index】: R739.7
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