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《Oncology Progress》 2018-02
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Study on the significance of CK7, TTF-1 and p63 expression in patients with nonsmall cell lung cancer

HAN Yongyan;LIU Rui;XU Linsong;NIE Tong;ZHANG Guirong;Department of Respiratory Medicine,Chaoyang Central Hospital;Department of Pathology, Chaoyang Central Hospital;  
Objective To observe the expression of cytokeratin 7(CK7), thyroid transcription factor-1(TTF-1) and p63 in patients with non-small cell lung cancer(NSCLC) and to analyze its clinical significance. Method The tissues from 80 cases of NSCLC patients were included in the analysis as NSCLC group, while the adjacent normal tissues were collected as control group. The positive expression rate of CK7, TTF-1 and p63 in NSCLC patients were determined, and the positive expression rates of CK7, TTF-1 and p63 in patients with different clinical and pathological characteristics were compared and analyzed to determine the factors influencing the positive expression rate of CK7, TTF-1 and p63 in NSCLC. Result The positive expression rate of CK7, TTF-1 and p63 in NSCLC tissues were markedly higher than that in control group, the difference was statistically significant(P0.001); The positive expression rates of CK7, TTF-1 and p63 differed significantly among patients with different TNM stages, presence of lymph node metastases, histological type, and degree of differentiation, demonstrating statistically significant difference(P0.05), there was no statistically significant difference in regard of the positive expression rate of CK7, TTF-1 and p63 in patients with different age and gender(P0.05); Multivariate analysis showed that, lymph node metastases and histological type were the factors influencing the positive expression of CK7, TTF-1 and p63 in patients with NSCLC(P0.05). Conclusion CK7, TTF-1 and p63 are highly expressed in patients with NSCLC, and are closely related to the lymph node metastases and histological classification.
【CateGory Index】: R734.2
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