Combined application of multiple tumor markers in the diagnosis of liver cancer
JIANG Lin;ZHANG Yina;FU Jun;Medical Examination Center, the First Affiliated Hospital of Harbin Medical University;
Objective To investigate the diagnostic value of 4 tumor markers, AFP, AFU, CEA and CA19-9, in detecting liver cancer. Method 70 liver cancer patients(liver cancer group), 80 patients with chronic liver disease(chronic liver disease group) and another 80 normal heathy adults(control group) were included in the analysis, of which the serum level of AFP, AFU, CEA and CA19-9 and the positive rate among the 3 groups, and between primary liver cancer and metastatic liver cancer patients were compared, to determine the diagnostic value of the combined application of multiple markers for liver cancer patients with HBs Ag(+) and HBs Ag(-). Result The serum level and positive rates of AFP,AFU, CEA and CA19-9 were higher in liver cancer group than that in control group and chronic liver disease group(P0.05). The serum AFP and AFU levels in primary liver cancer patients were significantly higher than that in metastatic liver cancer patients(P0.01), but the serum CEA was significantly lower than that in metastatic liver cancer patients(P0.01). Different combination of screening measures offered higher diagnostic sensitivity in detecting HBs Ag(+) liver cancer than HBs Ag(-) patients, in which the combination of"AFP + AFU + CEA"had the highest sensitivity(91.11%) and Youden index(0.80). Conclusion The diagnosing efficiency of"AFP + AFU + CEA"combination is fair enough for screening high-risk liver cancer patients, and may contribute to differentiate primary and metastatic liver cancer.
【CateGory Index】： R735.7