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《Oncology Progress》 2018-02
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Clinical study of esophageal peristalsis and changes of gastrointestinal hormones in patients with gastric cancer after resection

ZHU Sha;GE Hao;XU Yan;Department of Oncology, the Second People's Hospital of Wuxi;  
Objective To observe the esophageal peristalsis and gastrointestinal hormones in gastric cancer patients after surgery. Method 24 cases of gastric cancer patients who were administered with distal subtotal gastrectomy were included as study group, meanwhile, 25 cases of healthy volunteers were recruited as control group. The esophageal dynamics and the levels of gastrointestinal hormones were compared between the two groups. Result The resting pressure of lower esophageal sphincter(LES) in study group before surgery was significantly lower than that in control group, the difference was statistically significant(P0.05); besides, the resting pressure of LES of study group in 1 month after surgery was also lower than that in control group, with statistically significant difference observed(P0.05); in 3 months after surgery, the distal contractile integral(DCI) and contractile front speed of esophageal body, resting pressure of LES,complete relaxation pressure of esophagus were all significantly lower as compared with that in 1 month after surgery, before surgery and in control group, demonstrating significant difference(P0.05). The study group had higher level of motilin, while lower ghrelin than in control group(P0.05); while in 1 week and 3 months after surgery, the level of motilin,ghrelin, and leptin were significantly lower than that before surgery and in control group, all showed significant difference(P0.05); the motilin level in 3 months after surgery was higher than that in 1 week after surgery, and ghrelin was also lower in 1 week after surgery, the difference was statistically significant(P0.05). Conclusion The esophageal dynamics and gastrointestinal hormones in gastric cancer patients after surgery were decreased inconsistently, indicating underlying association.
【CateGory Index】: R735.2
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