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《Oncology Progress》 2018-08
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Value of micro-calcification in mammography on the diagnosis of breast ductal carcinoma in situ

LIU Hui;SHAO Xiaoli;LIU Jie;XU Changyan;SHA Hongmei;ZHUANG Xin;Department of Radiation,Panzhihua Central Hospital;  
Objective To investigate the value of micro-calcification in mammography in the diagnosis of ductal carcinoma in situ(DCIS). Method The clinical profiles of 163 patients with breast lumps who were hospitalized were retrospectively reviewed to evaluate the mammography and pathological findings, and the consistency of mammography and pathological findings in diagnosing benign and malignant tumors, as well as that of microcalcifications observed in mammography and DCIS in pathological examinations were analyzed. Result Mammography findings: 44 cases of benign tumors, 119 cases of malignant tumors. Pathological findings: benign tumors were observed in 37 cases, and there were 126 cases of malignant tumors. The consistency of mammography and pathological diagnosis for benign and malignant tumors was moderate(Kappa=0.492, t=6.323, P0.01). The sensitivity of breast cancer diagnosis was 84.92%(107/126),and specificity was 67.57%(25/37), the positive predictive value was 89.92%(107/119) and the negative predictive value was 56.82%(25/44). The consistency of micro-calcifications by mammography and pathological findings of DCIS was poor(Kappa=0.181, t=3.125, P0.01). The sensitivity of micro-calcifications in mammography for DCIS diagnosis was77.18%(21/27), with specificity being 55.15%(75/136), and the positive predictive value was 25.61%(21/82), the negative predictive value was 92.59%(75/81). Conclusion Mammography can be used as an effective procedure to screen breast cancer clinically. However, looking for micro-calcifications by mammography is with low efficiency, and should not be a standard for DCIS diagnosis.
【CateGory Index】: R730.44;R737.9
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