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《Oncology Progress》 2018-08
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Comparison of the clinical characteristics between thyroid cancer patients with Hashimoto thyroiditis and non-Hashimoto thyroiditis

LI Ruqiang;YUAN Geheng;GUO Xiaohui;Department of Endocrinology,the First Hospital of Peking University;Department of Endocrinology,Xinhua Hospital,Beijing Friendship Hospital,Capital Medical University;  
Objective To compare the clinical characteristics of patients with thyroid cancer combined with Hashimoto thyroiditis(HD) or non-Hashimoto thyroiditis(non-HD). Method The clinical data of 70 cases with HD and thyroid cancer(study group), and 209 cases with non-HD and thyroid cancer(control group) were retrospectively analyzed, the ultrasound characteristics, functional measures of thyroid as well as the pathological findings of the two groups were compared. Result More females were in study group than in control group, with statistically significant difference observed(P0.05). The levels of TSH, TGAb and TPOAb in serum of patients in study group were significantly higher than those in control group(P0.01). In regard of color Doppler ultrasound results, higher rate of microcalcification in control group(46.41%) was observed, and there were more patients with no calcification in study group(47.14%), the difference was of statistical significance(P0.05); in study group, poorly-defined margin were observed in 85.71% patients, which was higher than the 72.73% in control group, showing statistically significant difference(P0.05). Pathological findings showed that, the proportion of patients with non-nodular goiter was 90.00%, which was higher than that of 73.21% in control group, with statistically significant difference observed(P0.01). Conclusion HD combined with thyroid cancer develops in early age, and is more common in females, in ultrasound examinations, it is often with unclear thyroid margin,while few microcalcification were observed, which is helpful to improve the differential diagnosis of HD and non-HD complicated with thyroid cancer.
【CateGory Index】: R581.4;R736.1
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