Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Oncology Progress》 2018-08
Add to Favorite Get Latest Update

Effect of high performance progestogen on endometrial carcinoma/endometrial atypical hyperplasia and analysis of factors affecting pregnancy outcome

LI Mingming;WU Yumei;Department of Gynecology and Oncology,Beijing Obstetrics and Gynecology Hospital Affiliated to Capital Medical University;Department of Obstetrics and Gynecology,Heilongjiang Victoria Obstetrics and Gynecology Hospital;  
Objective To investigate the effect of high performance progestogen on endometrial carcinoma/endometrial atypical hyperplasia and to analyze the factors affecting pregnancy outcome. Method The clinical data of 37 cases of endometrial cancer(cancer group) and 35 cases of endometrial atypical hyperplasia(hyperplasia group) were selected and were retrospectively analyzed. Patients were treated with high performance progestogen medroxyprogesterone acetate on the premise of retaining the uterus. The natural pregnancy rate, artificial pregnancy rate, delivery rate and unpregnancy rate of the two groups within two years were compared. The Logistic regression analysis model was used to analyze the risk factors associated with pregnancy. Result The efficiency, inefficiency and recurrence rate of 37 patients in the cancer group were 91.9%, 8.1% and 2.7%, respectively. The efficiency, inefficiency and recurrence rate of 35 patients in the hyperplasia group were 100%, 0 and 2.9%, respectively. The natural pregnancy rate, artificial pregnancy rate, delivery rate and unpregnancy rate in the cancer group were 45.9%, 21.6%, 64.9% and 32.4% respectively within two years and the pregnancy rate was 67.6%. The natural pregnancy rate, artificial pregnancy rate, delivery rate and unpregnancy rate in the hyperplasia group were 60.0%, 22.9%, 77.1% and 17.1% respectively within two years and the pregnancy rate was 82.9%. Among 72 patients, there were 54 pregnancies and 18 unpregnancies. Compared to the unpregnancy patients,the allowed pregnancy age was lower, the curettage times and recurrence cases were less, the medication time and disease disappeared time were shorter and the endometrial thickness during ovulation was higher in pregnancy patients, all these differences were statistically significant(P0.05). Logistic analysis showed that the allowed pregnancy age, the endometrial thickness during ovulation and recurrence were independent risk factors affecting pregnancy of patients with endometrial carcinoma/endometrial atypical hyperplasia(P0.01). Conclusio Conclusion High performance progestogen has a significant effect in the treatment of endometrial carcinoma/endometrial atypical hyperplasia. The allowed pregnancy age, the endometrial thickness during ovulation and recurrence may be the independent risk factors affecting pregnancy.
【CateGory Index】: R737.33
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved