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《Oncology Progress》 2018-08
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Effect of intraperitoneal infusion of cisplatin combined with deep hyperthermia therapy on ovarian cancer and its effect on improvement of ascites

ZHANG Jinqiu;ZHANG Yipeng;HUANG Li;WANG Yanhua;Department of Gynecology,Qinhuangdao Maternal and Child Health Hospital;Department of Oncology,Qinhuangdao Traditional Chinese Medicine Hospital;  
Objective To investigate the effect of intraperitoneal infusion of cisplatin combined with deep hyperthermia therapy on ovarian cancer and its effect on improvement of ascites. Method The clinical data of 60 patients with ovarian cancer were retrospectively analyzed and divided into observation group(n=30) and control group(n=30) according to the treatment regimens. Patients in observation group received intraperitoneal infusion of cisplatin combined with deep hyperthermia therapy, patients in control group received simple intraperitoneal infusion of cisplatin therapy. The short-term effects, control of ascites, CA125 effective rate and the incidence of adverse reactions of patients in the two groups were compared and analyzed. Result The overall response rate(86.67%) and disease control rate(96.67%) in the observation group were significantly higher than those(63.33%, 80.00%) in the control group, the difference were statistically significant(P0.05). The ascites control rate(96.67%) and the effective rate of CA125(83.33%) were significantly higher in the observation group than those(80.00%, 60.00%) in the control group(P0.05). There was no significant difference in adverse events between the two groups(P0.05). Conclusion Intraperitoneal infusion of cisplatin combined with deep hyperthermia therapy in the treatment of ovarian cancer patients can significantly improve the short-term effects, improve the situation of ascites, and is without serious adverse reactions, which is worth of clinical application.
【CateGory Index】: R737.31
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