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《Oncology Progress》 2018-08
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Effect of anti-cancer soup combined with chemotherapy on the immune function and prognosis of patients with advanced oral cavity carcinomas after surgery

CAI Xiaoqing;CHANG Xiaoyun;GUO Lele;PEI Fei;SUN Qiang;Department of Oral and Maxillofacial Surgery,Zhengzhou Central Hospital Affiliated to Zhengzhou University;Department of Oral and Maxillofacial Surgery,the First Affiliated Hospital of Zhengzhou University;  
Objective To investigate the effect of anti-cancer soup combined with chemotherapy on the immune function and prognosis of patients with advanced oral cavity carcinomas after surgery. Method 60 cases with advanced oral cavity carcinomas after surgical treatment were enrolled in the study and were divided as control group or study group according to a random number table, with 30 cases in each. The patients in control group were given conventional chemotherapy, while those in study group were administered with compound traditional Chinese medicine anti-cancer soup and conventional chemotherapy at the same time, the two groups were treated for 8 consecutive weeks and followed up for 2 years. The clinical efficacy of the two groups were compared, the tumor marker level and proportion of T lymphocyte subsets were detected and compared, and the progression-free survival(PFS) of these patients during followup period were compared. Result After treatment, the overall response rate(RR) in study group reached 80.0%, which was higher than that of 53.3% in control group(P0.05), during follow-up, there were 8 cases of progressive disease(PD)in control group, and 2 cases in study group; the PFS rate of study group was higher than that of control group, and the difference had statistical significance(P0.05). Before treatment, the proportion of T lymphocyte subsets in the two groups was similar(P0.05). After treatment, the proportion of CD4~+cells, CD4~+/CD8~+ratio in control group decreased(P0.05), while the proportion of CD8~+cells increased(P0.05), though no statistically significant difference was observed for the proportion of CD56~+cells before and after treatment(P0.05). After treatment, the proportion of CD4~+cells and CD4~+/CD8~+ratio in study group were higher than those in control group, but the proportion of CD8~+was lower in study group compared with control group, showing statistically significant difference(P0.05); though the proportion of CD56~+cells in both groups after treatment was comparable, with no statistical significance observed(P0.05).Conclusion Anti-cancer soup combined with chemotherapy can effectively improve the immune function of patients with advanced oral cavity carcinomas after surgery, enhancing the clinical efficacy, and may increase the survival rate of patients at the same time.
【CateGory Index】: R739.8
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