PHAGOCYTOSIS AND INTRACELLULAR BACTERIOCIDAL FUNCTION OF NEUTRO.PHILS IN CHRONIC LIVER DISEASE
Tao Rongya, et al. (Department of Medicine, Affiliated Hospital of Bengbu Medical College, Anbui)
Yeast cells were used for examining phagocytosis and intraccllular bacteriocidal function of neutrophils in 44 cases of cirrhosis, 10 chronic persistent hepatitis and 38 normal subjects as controls. The mean value of phagocytosis and killing rates of ncutrophils were 23 ± 7 and 39 ± 3 respectively in controls, and 15±5 and 30±7 respectively in the cirrhosis The values were significanlly lower in the cirrhosis and much higher in chronic hepatitis than those in controls, but there was no marked difference among all kinds of cirrhosis. The effect of liver cirrhosis on the function of ncutrophils is still not clear. According to the detection of TgA (15 cases) and C3 ( 10 cases), it was found that the level of IgA was significanlly higher and C3 was much lower than those in controls. Tin's indicates that the susceptibility of cirrhosis patient is due to the abnormality in phagocytosis and killing ability of ncutrophils, which may be correlated with the increase in IgA and/or decrease in C3.