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《Journal of Bengbu Medical College》 2004-01
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The antitumor effect of AC-88 in mice bearing cancer and its effect on T cell Fas expression

MA Dong zhu,SUN Ke ren,ZHAO Li,XIAO Zhi feng,LI Hui (Department of Hygiology,Bengbu Medical College,Anhui 233003,China)  
Objective:To investigate the antitumor effect and possible mechanism of AC 88.Methods:H22,Meth A,EAC cell bearing mice in vivo and LOVO,TYK,H22 culture cells in vitro were used to study the antitumor effect of AC 88 and Western blotting was used to study Fas expression of T lymphocytes.Results:The antitumor rate of AC 88 250 mg/kg group on three types tumor bearing mice was 76.31%,73.52%,and 71.91 %,respectively.The average tumor weight was lower than control group( P 0.01).The IC 50 of AC 88 on each type tumor cells was lower than 10 μg/ml in vitro .Fas expression of T cells was decreased in the same time( P 0.01).Conclusions:AC 88 has obvious antitumor effect and maybe through decrease T cell Fas expression.
【Fund】: 山东省九五攻关课题资助项目 ( 819 0 5 0 3 )
【CateGory Index】: R73-36
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1 LIU Yan~1,YAO Wen-huan~2,SUN Ke-ren~3 (1.National Institute for the Control Pharmaceutical and Biological Products, Beijing 100050,China;2.Shandong Center for Disease and Prevention,Jinan 250014,China;3.School of Public Health Shandong University,Jinan 250012,China);The Anti-tumor Effect of New Kind of DHA Compound and Its Effect on Caspase-3 Expression[J];Chinese Journal of Comparative Medicine;2009-03
【Citations】
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1 MA Dong-zhu, SUN Ke-ren, ZHAO Li, XIAO Zhi-feng, LI Hui (Department of Toxicology, Shandong University, Jinan 250012 );Effect of AC-88 on the Expressions of Fas, NF-KB/I-κB in T Lymphocytes of the Tumor-Bearing Mice[J];Shanghai J.of Immunology;2002-04
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1 MA Dong-zhu, SUN Ke-ren, ZHAO Li, XIAO Zhi-feng, LI Hui (Department of Toxicology, Shandong University, Jinan 250012 );Effect of AC-88 on the Expressions of Fas, NF-KB/I-κB in T Lymphocytes of the Tumor-Bearing Mice[J];Shanghai J.of Immunology;2002-04
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