Effect of dose of neostigmine on recovery from atracurium-induced neuromuscular blockade

ZHU Fan,SHEN Liang,FU Wei an (Department of Anesthesiology,Luwan Branch,Ruijin Hospital,Affiliated to Shanghai Second Medical University,Shanghai 200020,China)  

Objective:To investigate the effect of dose of neostigmine administration on recovery from atracrium induced neuromuscular blockade.Methods:Thirty patients(ASA Ⅰ and Ⅱ) were divided into three groups(each ten),and received neostigmine 20 μg/kg,35 μg/kg and 50 μg/kg,respectively.Results:The speed of recovery from atracurium induced neuromuscular blockade with neostigmine 20 μg/kg was lower as compared with 35 μg/kg and 50 μg/kg,but the difference was not significant between with neostigmine 35 μg/kg and 50 μg/kg.Conclusions:Recovery from atracurium induced neuromuscular blockade was accelerated when dose of neostigmine was increased from 20 μg/kg to 50 μg/kg,35 μg/kg is the optimal dose of neostigmine for reversal of atracurium induced neuromuscular blockade.

【CateGory Index】： R96

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