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《Journal of Bengbu Medical College》 2004-04
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Influence of epidural anesthesia combined with isoflurane on hepatic ischemia-reperfusion injury

LI Xiao-hong,JIN Zhong,XUE Mei,WANG Nan-hai (Department of Anesthesiology,Affiliated Hospital of Bengbu Medical College,Anhui 233004,China)  
Objective:To determine if epidural anesthesia combined with isoflurane has protective effect on hepatic ischemia-reperfusion injury.Methods:Thirty-six patients with hepatocellular carcinoma were randomized to epidural anesthesia combined with isoflurane group(group E,n=18) and general anesthesia group(group G,n=18).Continuous epidural anesthesia(CEA) was performed at T (8-9) with F 3 in group E.In both groups,anesthesia was induced with midazolam,fentanyl,propofol and vecuronium.The SBP,DBP,HR,IL-6 level and the changes of liver function were measured respectively before anesthesia,after tracheal intubation,pringle maneuver,open pringle maneuver and at the end of operation.Results: The hemodynamic changes were not significant in group E(P0.05 to P0.01);Serum IL-6 concentrations increased significantly the moment after tracheal intubation and at the end of operation in group G,compared to those in group E(P0.05 to P0.01).The activities of serum aspartate transaminase(AST),alanine transaminase(ALT) increased markedly after reperfusion,compared with those before ischemia in the two groups(P0.01).Conclusions:Epidural anesthesia combined with isoflurane can reduce the stress response and produce protective effects on the hepatic ischemia-reperfusion injury to some extent.
【CateGory Index】: R614.42
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