Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Bengbu Medical College》 2006-05
Add to Favorite Get Latest Update

Effect of COMxEP regimens in treating non-Hodgkin's lymphoma

HUANG Zhu-hua,ZHOU Zheng-guang,CHEN Juan,ZHAO Lun(Department of Medical Oncology,Affiliated Hospital of Bengbu Medical College,Bengbu 233004,China)  
Objective:To evaluate the therapeutic effect and toxicity of COMxEP regimens in treatment of non-Hodgkin's lymphoma(NHL).Methods:Thirty-seven patients with intermediate-high grade NHL were treated with a combination chemotherapy of COMxEP.COMxEP regimen consisted of VP_(16),60-70 mg/m~2(iv gtt,Day1-5);MxT,6-8 mg/m~2(iv gtt,Day1);VCR,1.4 mg/m~2(iv,Day1,8);CTX,600-800 mg(iv,Day1,8);Pred,40-60 mg/day(po,Day1-5).One course lasted for 4 weeks and each patient received(4.8) courses on the average.Results:In the thirty seven patients receiving COMxEP regimen,complete remission(CR) rate was(67.6%),partial remission(PR) rate 21.6%,SD rate 14.3% and PD was no,and the overall response rate was 89.2%(33/37),with a median duration of 26 months.In the patients with refractory disease,CR rate was 53.8%,PR rate 30.8%,SD rate 15.4% and PD was no,and the overall response rate was 84.6%.The main side effects were bone marrow depression,enteron reaction and alopecie.Conclusions:COMxEP regimen is effective for patients with newly diagnosed or refractory disease,and the toxicity is tolerable.This regimen can be considered as a routine or salvage therapy for intermediate-high grade NHL.
【CateGory Index】: R733.1
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 1 Hits
1 Chen Tong1,2 Hou Shixiang3 Wang Yongyan1 Zhang Wensheng1 Liao Hui31(Institute of Resources Medicine and Chinese Medical Resources,Beijing Normal University,Beijing 100875,China) 2(Faculty of Pharmaceutical Sciences,Kunming Medical College,Kunming 650031,China)3(Department of Pharmaceutics Sciences,School of Pharmacy,Sichuan University,Chengdu 610041,China);Therapeutic Effect and Toxicity of Compound Vincristine Liposome on Breast Cancer in Nude Mice[J];Journal of Biomedical Engineering;2009-01
【Citations】
Chinese Journal Full-text Database 3 Hits
1 Shen Zhixiang; Wang Jin; Mi Jianqing,et al (Department of Hematolegy, Ruijin Hospital, Shanghai Second Medical University, Shanghai(200025));The Effectiveness of EMCOP in Treating Malignant NHL[J];ACTA UNIVERSITATIS MEDICINALIS SECONDAE SHANGHAI;1997-05
2 WANG Qilu, ZHOU Liqiang, HE Xiaohui, et al. Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021;Clinical analysis of 935 cases of non Hodgkin's lymphoma[J];CHINESE JOURNAL OF ONCOLOGY;1999-02
3 CHEN Shao-feng,LAO Yi,HU Jian-xin,ZHONG Hai-ming Department of Medical Oncology,The Central Hospital of Guangdong Province Agricultural Reclamation, Zhanjiang 524002,China;Clinical Comparison of CHOP Plus Oral VP-16 Regimen and CHOP Regimen for Adverse Prognostic Factor Non-Hodgkin's Lymphoma[J];Cancer Research On Prevention and Treatment;2004-09
【Co-references】
Chinese Journal Full-text Database 4 Hits
1 Wu Da Long, Huang Feng, Lu Huan Zhang Department of Clinical Pharmacology,Affiliated Hospital, Academy of Military Medical Sciences,Beijing,100039, P.R.China;Drug Resistant Proteins in Breast Cancer:Recent Progress in Multidrug Resistance[J];Chinese Journal of Cancer;2003-04
2 Shen Zhixiang; Wang Jin; Mi Jianqing,et al (Department of Hematolegy, Ruijin Hospital, Shanghai Second Medical University, Shanghai(200025));The Effectiveness of EMCOP in Treating Malignant NHL[J];ACTA UNIVERSITATIS MEDICINALIS SECONDAE SHANGHAI;1997-05
3 GAO Shu, RONG Long-Fu,JIN Yong,YAO Hong-Wei,GUO Lin,LI Jun-(School of Pharmacy,Anhui Medical University,Hefei 230032)--;Study of pharmacokinetics of AZT in mice by encapsulation in liposomes Containing galactosylceramide[J];Chinese Pharmacological Bulletin;2004-02
4 CHEN Tong~1,HOU Shi-xiang~(2*),WANG Yong-yan~1,ZHANG Wen-sheng~1,CHEN Dong-hui~3(1.College of Resource Science and Technology,Beijing Normal University,Beijing 100875,China;2.Wast China School of Pharmacy,Sichuan University,Chengdu 610041,China;3.Sichuan Institute of Chinese Materia Medica,Chengdu 610041,China);Release profile of compound liposomes entrapped with vincristine sulfate and mitoxantrone chlorhydric acid in vitro and their distribution in mice[J];Acta Pharmaceutica Sinica;2006-12
【Secondary Citations】
Chinese Journal Full-text Database 4 Hits
1 LIN Tong yu,GUAN Zhong zhen,JIANG Weng qi,et al Cancer Center,Sun Yat sen University of Medical Sciences,Guangzhou 510060,P R China$$$$;Randomized clinical trial of standard CHOP regimen and biweekly intensified CHOP regimen in the treatment of aggressive non Hodgkin's lymphoma[J];CHINESE JOURNAL OF CANCER;1999-06
2 LIN Tongyu, CUAN Zhongzhen, HE Youjian,et al Cancer Center,Sun Yatsen University of Medical Sciences,Guangzhou 510060,China;Suitability study of the international prognostic index(IPI) in aggressive nonHodgkin's lymphoma of Chinese[J];CHINESE JOURNAL OF CANCER;1999-03
3 Wang Zi′an Wang Jing Yu Donghong Department of Medical Oncology, Anhui Tumor Hospital, Bengbu;Treatment of Obstinate Remained Tubercle of Lymphoma by Intratumoral Injection of BLM_(A5)[J];CHINESE JOURNAL OF CLINICAL ONCOLOGY;1999-08
4 WANG Qilu, ZHOU Liqiang, HE Xiaohui, et al. Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021;Clinical analysis of 935 cases of non Hodgkin's lymphoma[J];CHINESE JOURNAL OF ONCOLOGY;1999-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved