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《Journal of Bengbu Medical College》 2006-05
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Study on the efficacy and safety of doxifluridine in treatment of advanced gastric cancer and colorectal cancer

FANG Jia-hua(Department of Oncology,Anqing Second People's Hospital,Anqing 246003,China)  
Objective:To evaluate the efficacy and safety of doxifluridine in treatment of old and weak patients with advanced gastric and colorectal cancer.Methods:Twenty cases of advanced gastric and colorectal cancer were given doxifluridine 200 mg four times daily for 14 days,followed by a week rest.The regime was repeated for 2-3 cycles.Results:Among the patients,CR was found in 0 cases,PR in 6 cases,SD in 9 cases and PD in 5 cases.the overall response rate was 30%.There were few adverse events.WHO grade Ⅰ/Ⅱ leukopenia occurred in 5 cases(25%),grade I thrombocytopenia occurred in 2 cases(10%),gradeⅠ/Ⅱ nausea and vomiting in 3 cases(15%),and the damage to the liver and kidney and heart function was not obvious.Conclusions:Doxifluridine has certain effect on patients with advanced gastric and colorectal cancer,with slight toxin or side effects.
【CateGory Index】: R735
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