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《Journal of Bengbu Medical College》 2006-05
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Continuous venous infusion of low-dose of 5-fluorouracil and cisplatin for treatment of advanced gastric cancer

XIA Xiao-yang,YE Ai-he,CHEN Ai-min,XU Jing(Department of Oncology,Chuzhou Second People's Hospital,Chuzhou 239001,China)  
Objective:To assess the efficacy and toxicity of a combination therapy of continuous venous infusion(civ) of low-dose of 5-fluorouracil(5-Fu)and cisplatin in treatment of advanced gastric cancer.Methods:The regimen consisted of 5-Fu 250 mg·m~(-2)·d~(-1) civ,and PDD 6 mg·m~(-2)·d~(-1),5 d/w,which were used for 3 weeks.The effect and the toxicity were evaluated after 2 cycles of treatment.Results:Gross efficiency rate was 52.8% in 1 the case of CR and 18 cases of PR.The Major toxic effect was gastrointestinal tract reaction.Repression of marrow was light.Conclusions:The chemotherapy regimen mentioned above is effective and has little toxic effect.It is suitable for treatment of advanced gastric cancer.
【CateGory Index】: R735.2
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