Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Qingdao University(Medical Sciences)》 2018-03
Add to Favorite Get Latest Update

ASSOCIATION OF SERUM URIC ACID WITH INSULIN RESISTANCE AND OBESITY IN MALE PATIENTS WITH TYPE 2 DIABETES MELLITUS

CHENG Bingfei;MU Zepeng;WANG Yan′gang;Department of Endocrine and Metabolic Diseases,The Affiliated Hospital of Qingdao University;  
Objective To investigate the association of serum uric acid(SUA)with insulin resistance and obesity in male patients with type 2 diabetes mellitus(T2DM). Methods A total of 188 hospitalized male patients with T2DM were enrolled and divided into normal SUA group(group A)and hyperuricemia(HUA)group(group B)according to their SUA levels,and relevant clinical indices were compared between the two groups. Results Compared with group A,group B had significantly higher body mass index(BMI)and insulin resistance index(HOMA-IR)and significantly a lower testosterone level(t=-2.29 to 4.97,P0.05).The SUA level was positively correlated with BMI and HOMA-IR(r=0.144-0.477,P0.05),but negatively correlated with testosterone level(r=-0.215,P0.05).Logistic regression analysis indicated that BMI and HOMA-IR were indepen-dent risk factors for HUA in male patients with T2DM.Empower Stats was used to find the thresholds of HOMA-IR and BMI that induced high uric acid levels.The results showed that 1 unit increase in HOMA-IR resulted in an increase in SUA level by 8.2μmol/L;when BMI was higher than 20.8 kg/m~2,an BMI increase of 1 kg/m~2 resulted in an increase in SUA level by 11.3μmol/L. Conclusion The risk of HUA in male patients with T2DM is associated with insulin resistance and obesity.
【Fund】: 国家自然科学基金面上项目(81571625)
【CateGory Index】: R587.2;R589.2
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved