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《青岛医学院学报》 1998-04
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ULTRACYTOCHEMICAL STUDY OF LARGE DOSE OF TESTOSTERONE ON FEMALE MICE KIDNEY

Yu Xiangmin,Wang Wenqing,Tan Jinshan, et al Department of Histology and Embryology,Qingdao Medical College, Qingdao 266021  
Objective To observe the effect of large dose testosterone on cellular enzyme activities of female mice kidney. Methods The mitochondrial marker enzyme (cytochrome C oxidase), and the plasma membrane marker enzyme (Na~+,K~+-ATP) of renal tubules were studied with EM enzymatic cytochemistry in female mice andministrated with large dose of androgen. Results The dense granules of cytochrome C oxidase were clearly seen in both the proximal and distal tubules of control group. While in the testerone group, the granule density was greatly decreased, some located on the broken cristae of mitochondria. The Na~+,K~+-ATPase activitity decreased considerably in the plasma membrane infolding of proximal and distal tubule compared with the normal group. Conclusion Large dose of testosterone can cause ultrastructural changes of renal tubules and weaken some important enzyme activities.
【CateGory Index】: R977.4
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