EFFECTS OF MAGNESIUM SULFATE ON BLOOD PRESSURE AND PLASMA ENDOTHELIN(ET-1) CONCENTRATION OF HYPERTENSION PATIENTS

Chen Xianghong,Cai Zhirong, Guo Yinghua, et al Department of Cardiology, The Affiliated Hospital of Qingdao Medical College, Qingdao 266003  

Objective To investigate the effects of acute intravenous dripping administration of magnesium sulfate on blood pressure and plasma endothelin(ET-1) concentration. Methods The effects of acute intravenous dripping administration of 25%magnesium sulfate 10ml (Mg2+ 4.88mmol) on plasma endothelin1(ET1) concentration,systolic and diastolic blood pressure (SBP and DBP) were studied in 10 subjects with mild and medium degree of systemic hypertension, using a random, selfplacebocontrolled,doubleblind, crossover design. Results Compared with pretreatment and placebotreated group, magnesium sulfate decreased significantly SBP, DBP(t=2.53—5.27, P0.05, 0.01) and plasma ET-1 concentration(t=2.53—5.27,P0.05,0.01. Conclusion The results indicate that the lowering of plasma ET-1 concentration may be one of the mechanisms of antihypertensive effects of maganisium sulfate.

【CateGory Index】： R544.1

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