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《青岛医学院学报》 1999-01
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THE INFLUENCE OF KADSURENONE UPON BLASTOCYST IMPLANTATION IN MICEIMMUNOHISTOCHEMICAL STUDIES

Wu Mei,Wang Wenqing,Wu Cuijiao, et al\ Department of Histology and Embryology, Qingdao Medical College, Qingdao 266021\;  
\ Objective \ To investigate the influence of Kadsurenone (an antagonist of platelet activity factor PAF) upon implantation of mouse blastocyst.\ Methods \ Fiftytwo female healthy mice, mating with male healthy mice of the same breed, in proportion as 2 to 1. The 1st day of pregnancy was determined by the presence of vaginal plug. On the 2nd day of pregnancy, Kadsurenone in different dosages were injected into the uterohorn of one side of mice, equal amount of physiological saline were injected into the uterohorn of the other side. On the 8th day or the 10th day of pregnancy, the histological changes of uterus as well as fetus were observed after the tissue being treated with immunohistochemistry.\ Results \ In the experimental groups with Kadsurenone 20L, the decidua became thinner , Laminin immunoreactivity reduced, while fibronectin immunoreactivity increased, in association with retarded development and even retrogressive degeneration of mouse fetuses compared with the control groups. In groups with Kadsurenone40L, there's no decidualization of uterus, the blastocyst was digsested. \ Conclusion \ By the mechanism of antiPAF , Kadsurenone impaired the decidualization of uterus and influenced on the composition and distribution of extracellular matrix(e.g. Ln and Fn), which might be one of the mechanisms of Kadsurenone against implantation. \
【Fund】: 山东省自然科学基金
【CateGory Index】: R965
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