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《青岛医学院学报》 1999-01
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DETECTION OF P53 GENE AND HUMAN PAPILLOMAVIRUS HPV16 IN MEIBOMIAN GLAND CARCINOMAS

Yan Ying, Niu Yingjun, Ji Jianzhong, et alDepartment of Ophthalmology, The Affiliated Hospital of Qingdao Medical College, Qingdao 266003  
Objective To inquire into the molecular biological mechanisms of the occurrence of meibomian gland carcinomas. Methods Using polymerase chain reactionrestriction fragment length polymorphisms(PCRRFLP) method, we studied 248 points in 34 samples ( including 17 meibomian gland carcinomas,17 chalazions). DNA segment of HPV16 was also detected by PCR technique. Results 29.5% meibomian gland carcinoma were shown to contain point mutation in P53 gene, no point mutation was found in chalazions, the difference was significant (P=0.022).No significant correlation was found between the P53 gene mutations and the clinical pathological manifestations of meibomian gland carcinomas (P0.05). No HPV16 DNA was found in meibomian gland carcinomas. Conclusion P53 gene mutations might play roles in the early stage of the development of meibomian gland carcinomas. No correlation between P53 gene mutations and clinical manifestations was found.
【Fund】: 青岛市科委资助
【CateGory Index】: R730.23
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