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《青岛医学院学报》 1999-01
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THE EXPRESSION OF P53 PROTEIN AND DNA CONTENT ANALYSIS IN ANGIOIMMUNOBLASTIC LYMPHADENOPATHY

Zhang Hua, Ji Xiangrui, Jiang Tianfu, et al\ Department of Pathology, The Affiliated Hospital of Qingdao Medical College, Qingdao 266003\;  
\ Objective \ To investigate the expression of P53 protein and DNA content in angioimmunoblastic lymphadenopathy(AIL) and discuss the nature and pathogenesis of AIL.\ Methods \ Immunogenotype and P53 protein expression were detected by immunohistochemistry technique, and DNA content was determined by image analysis in 20 cases of AIL. 10 cases of reactive lymphoproliferation and 20 cases of nonHodgkin's lymphoma(NHL) were studied as controls.\ Results \ The positive rate of P53 protein in AIL was 30%(6/20), which had no correlation with the prognosis of patients. DNA content was significantly associated with the prognosis of AIL patients(t=2.864, P0.05). The positive expression of P53 protein and DNA content showed significant difference between AIL and NHL (2=4.912, t=3.552, P0.05). DNA content in P53 protein positive cases were significantly higher than that of P53 protein negative cases(t=2.226, P0.05).\ Conclusions \ P53 gene and DNA content were involved in the pathogenesis and malignant transformation of AIL. AIL may be a kind of clinical syndrome caused by different diseases.\;
【CateGory Index】: R551.2,R551.2
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