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EXPRESSION OF CD44v IN GASTRIC ADENOCARCINOMA AND ITS CLINICAL SIGNIFICANCE

Jin Weizhong, Zhao Jingxuan, Yang Donghui, et al\ Department of Pathology, No. 401 Hospital of PLA, Qingdao 266071\;  
\ Objective \ To study the expression of CD44v in gastric adenocarcinoma and its relationship with lymph node metastasis and prognosis of patients.\ Methods \ Expressions of CD44v6 in 105 cases of gastric adenocarcinoma were observed by SP immunohistochemistry.\ Results \ The incidence of CD44v6 protein positivity in gastric adenocarcinomas was 48.6%. The expression of CD44v6 protein was related with the differentiation, depth of invasion, TNM stage and prognosis of gastric adenocarcinoma(2=4.41-8.97, P0.05), and was significantly correlated with metastasis to lymph nodes (2=9.23, P0.01).\ Conclusion Expression of CD44v6 might be a useful indicator of gastric adenocarcinoma metastasis to lymph node and the prognosis of patients.\
【CateGory Index】: R735.2
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