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《青岛医学院学报》 1999-01
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EFFECT OF PROPLYLENE GLUCOL MANNURATE SULPHATE ON GLUTAMATE TRANSPORTER FUNCTION OF HIPPOCAMPUS IN ISCHEMIAREPERFUSION INJURED RATS

Ren Xiaoyan, Xu Luo, Zhang Yumin, et alDepartment of Pathophysiology, Qingdao Medical College, Qingdao 266021  
Objective To investigate the effect of proplylene glucol mannurate sulphate( PGMS) on glutamate transporter function of hippocampus in ischemiareperfusion injured (I120R30) rats. Methods The brain ischemiareperfusion model of rat was made by clipping and releasing three arteries.Glutamate transporter function was studied by assay of 3HLglutamate uptake in hippocampus synaptosomes. MDA contents and SOD activities were detected by spectrophotometry. Results The glutamate transporter function and SOD activities of hippocampus in ischemiareperfusion rats were significantly decreased(t=4.482,3.691,P0.01), contents of MDA were increased(t=3.067,P0.05) compared with control group. Glutamate transporter function and SOD activity in PGMS group were increased(t=3.127,2.938,P0.05), contents of MDA were decreased(t=3.067,P0.05) compared with ischemiareperfusion rats. Conclusion PGMS can improve glutamate transporter function of ischemiareperfusion rats through the elimination of free radicals.
【Fund】: 国家自然科学基金
【CateGory Index】: R363
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【References】
Chinese Journal Full-text Database 1 Hits
1 LIU Yan,XU Luo(Department of Pathophysiology,Qingdao University Medical College,Qingdao 266021,China);THE ROLE OF SEPTAL NUCLEUS IN Ghrelin-REGULATED ABILITY OF LEARNING AND MEMORY IN HIPPOCAMPUS OF RATS[J];Acta Academiae Medicinae Qingdao Universitatis;2011-06
【Secondary References】
Chinese Journal Full-text Database 2 Hits
1 DING Mingchen,XU Luo(Qingdao University Medical College,Qingdao 266021,China);EFFECT OF GHRELIN OF LATERAL SEPTAL NUCLEUS ON REGULATION OF GASTRIC MOTILITY IN RATS[J];Acta Academiae Medicinae Qingdao Universitatis;2012-01
2 ZHAO Zhihong,LIU Tianwei,MA Zegang,ZHAO Renliang,ZHOU Yu(Department of Physiology,Qingdao University Medical College,Qingdao 266021,China);EFFECT OF CHRONIC GHRELIN ADMINISTRATION ON RECOGNITION OF NEW OBJECT AND LOCATION IN MICE[J];Acta Academiae Medicinae Qingdao Universitatis;2013-03
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