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Map3k1 Regulation of Mouse Eyelid Closure

WU Liu-Cheng① SHAO Yi-Xiang①② ① Laboratory Animals Centre,Nantong University,Nantong 226001; ② Institute of Comparative Medicine,Nantong University,Nantong 226001,China  
The development of the eyelid requires coordinated processes of cell proliferation,morphology changes,migration and cell death.Map3k1 is an important member of MAPK family and its protein,MEKK1,is a crucial cross-point in MAPK signal pathway.MEKK1-JNK signal pathway regulates actin filament formation and cell migration through enhancing the transcriptional activity of Ap-1.Moreover,MEKK1 has a possible interaction with HB-EGF/EGFR-ERK by c-jun.The Map3k1 knockout mouse is defective in embryonic eyelid closure,and Map3k1 mutant results in the postnatal corneal disease in mouse.Thus,study of Map3k1 function provides a new perspective for human congenital eyelid defects and the corneal disease,and sheds the new light on early diagnosis,prevention,and therapy of this disease.
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