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《Chinese Journal of Zoology》 2011-03
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Map3k1 Regulation of Mouse Eyelid Closure

WU Liu-Cheng① SHAO Yi-Xiang①② ① Laboratory Animals Centre,Nantong University,Nantong 226001; ② Institute of Comparative Medicine,Nantong University,Nantong 226001,China  
The development of the eyelid requires coordinated processes of cell proliferation,morphology changes,migration and cell death.Map3k1 is an important member of MAPK family and its protein,MEKK1,is a crucial cross-point in MAPK signal pathway.MEKK1-JNK signal pathway regulates actin filament formation and cell migration through enhancing the transcriptional activity of Ap-1.Moreover,MEKK1 has a possible interaction with HB-EGF/EGFR-ERK by c-jun.The Map3k1 knockout mouse is defective in embryonic eyelid closure,and Map3k1 mutant results in the postnatal corneal disease in mouse.Thus,study of Map3k1 function provides a new perspective for human congenital eyelid defects and the corneal disease,and sheds the new light on early diagnosis,prevention,and therapy of this disease.
【Fund】: 国家自然科学基金项目(No.30671081);; 江苏省自然科学基金项目(No.BK2010279);; 南通大学研究生科技创新计划项目(No.YKC10015)
【CateGory Index】: Q954.4
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 Shao Yixiang~(1,2),Wu Baojin~1,Xue Zhengfeng~1,Chen Bing~1,Mao Huihua~1,Zhao Ming~1,Li Houda~1(1.Comparative Medicine Center,Yangzhou University,Yangzhou 225009,China)(2.Laboratory Animal Center,Nantong University,Nantong 226001,China);The New Mutation Mouse with Heritable Disease of Cornea Matrix Denaturalization and the Mapping of Mutation Gene[J];Journal of Nanjing Normal University(Natural Science);2006-02
2 JIANG Ying-Mei1,LIU Chun2,WU Liu-Cheng1,SHAO Yi-Xiang1,2 1.Laboratory Animals Centre,Nantong University,Nantong 226001,China;2.Institute of Comparative Medicine,Nantong University,Nantong 226001,China;Fine mapping of mutant gene related corneal opacity mouse with SNPs[J];Hereditas;2010-05
【Co-citations】
Chinese Journal Full-text Database 7 Hits
1 ZHU Shun-xing et al(Laboratory Animal Center,Nantong University,Nantong,Jiangsu 226001);Expression and Significance of Vascular Endothelial Growth Factor in B6-Co Mouse Cornea[J];Journal of Anhui Agricultural Sciences;2010-26
2 WU Liu-cheng1,LIU Chun2,JIANG Ying-mei1,WANG Sheng-cun,SHAO Yi-xiang1,2(1.Laboratory Animals Centre,Nantong University,Nantong,Jiangsu,226001,China;2.Institute of Comparative Medicine,Nantong University,Nantong,Jiangsu,226001,China);Cloning and Sequence Analysis of Mutant Candidate Gene of Map3k1 in Cornea Opacity Mouse[J];Progress in Veterinary Medicine;2011-04
3 YIN Xiaomin,GUAN Huaijin1,SHAO Yixiang2 (Department of Ophthalmology, Chinese Medicine Hospital of Taizhou,Jiangsu 225300; 1Department of Ophthalmology, Affiliated Hospital of Nantong University;2Laboratory Animal Center of Nantong University);The bacteriological research of B6-Co mouse with corneal opacity[J];Medical Journal of Communications;2008-06
4 TANG Jian-zhong1,ZHU Chang-Lai2,SHAO Yi-Xiang3,GUAN Huai-Jin1,Lin Lin2,ZHANG Tian-Yi2(1Affiliated Hospital of Nantong University,2Key Laboratory of Neuroregeneration of Nantong University,3 Laboratory Animal Center of Nantong University;Nantong 226001,China);Observation of ultramicro-pathology in the keratitis model of mouse with genetic deficiency[J];Chinese Journal of Clinical and Experimental Pathology;2008-05
5 1,2ZHU Shunxing, 1SUN Li, 1,2LIU Chun, et al (1Laboratory Animal Center, Nantong University, Nantong 226001;2Research Insititute of Comparative Medicine, Nantong University, Nantong 226001);To accumulate basic knowledge of biological characteristics of congenital corneal opacity mice[J];Acta Academiae Medicinae Nantong;2009-02
6 SHAO Yi-xiang1,YIN Xiao-min2,WANG Chun-zhong1,JIANG Ying-mei1,GUAN Huai-jin2(1.Laboratory Animal Center of Nantong University,Institute of Comparative Medicine of Nantong University;2.The Affiliated Hospital of Nantong University.Nantong 226001,China);A Study on Keratonosus Pathogens in B6-Co Mice[J];Laboratory Animal and Comparative Medicine;2008-05
7 JIANG Ying-Mei1,LIU Chun2,WU Liu-Cheng1,SHAO Yi-Xiang1,2 1.Laboratory Animals Centre,Nantong University,Nantong 226001,China;2.Institute of Comparative Medicine,Nantong University,Nantong 226001,China;Fine mapping of mutant gene related corneal opacity mouse with SNPs[J];Hereditas;2010-05
【Secondary Citations】
Chinese Journal Full-text Database 8 Hits
1 Shao Yixiang~(1,2),Wu Baojin~1,Xue Zhengfeng~1,Chen Bing~1,Mao Huihua~1,Zhao Ming~1,Li Houda~1(1.Comparative Medicine Center,Yangzhou University,Yangzhou 225009,China)(2.Laboratory Animal Center,Nantong University,Nantong 226001,China);The New Mutation Mouse with Heritable Disease of Cornea Matrix Denaturalization and the Mapping of Mutation Gene[J];Journal of Nanjing Normal University(Natural Science);2006-02
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4 WU Bao-jin 1, MAO Hui-hua 1, XUE Xiao-ping 2, ZHU Hong 1, YAN Zhi-feng 1, YANG Lin 1, SUN Qiang 1, XU Xiang-ming 1, XUE Zheng-feng 1, LI Hou-da 1 (1.The Comparative Medicine Center of Yangzhou University,Yangzhou 225009,China; 2.Clinical Laboratory of Yangzhou University Medical College);Preliminary Study of Mice Mutation Induced by ENU[J];Acta Laboratorium Animalis Scientia Sinica;2003-03
5 WU Bao-jin,MAO Hui-hua,ZHU Hong,YAN Zhi-feng, YANG Lin,SUN Qiang, XU Xiang-ming, XUE Zheng-feng, LI Hou-da (The Comparative Medicine Center of Yangzhou University, Yangzhou 225009, China);PCR Conditions and Application of 39 Mouse Microsatellites[J];Acta Laboratorium Animalis Scientia Sinica;2003-04
6 XU Qian, SUN Li-Ping, GONG Yue-Hua, XU Ying, DONG Nan-Nan, YUAN Yuan Cancer Control Laboratory of Cancer Institute and General Surgery Institute, the First Affiliated Hospital of China Medical University, Shenyang 110001, China;The relationship between the polymorphism of MUC1 and suscepti-bility to gastric cancer in Liaoning region[J];Hereditas;2008-09
7 GUO Xiao-Ling,CHEN Zhe,ZHAO Xiao-Feng,XU Ning-Ying College of Animal Science,Zhejiang University,Hangzhou 310029,China;Effect of SNP in the exon 8 of SIM1 gene on backfat thickness in pigs[J];Hereditas;2008-06
8 GUAN Hong-Ying, TANG Zhi-Quan, LI Hui① College of Animal Science, Northeast Agricultural University, Harbin 150030, China;Correlation Analysis Between Single-Nucleotide Polymor-phism of Malate Dehydrogenase Gene 5′-Flanking Region and Growth and Body Composition Traits in Chicken[J];Acta Genetica Sinica;2006-06
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