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《Journal of Beijing Polytechnic University》 2004-01
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Design of Protein in Off-lattice Model

LIU Yun, WANG Cun-xin, WANG Bao-han, CHEN Wei-zu (College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100022, China; Research Institute of Biophysics (IBP), Chinese Academy of Sciences, Beijing 100101, China )  
In order to overcome the difficulty of applying dual Monte Carlo method to the bigger molecule system and off-lattice model, a simple new method of protein design based on relative entropy is proposed. This method completely based on the principles of Physics adopts the off-lattice model and takes 16 real protein in the natural and stable state as the target structure to test and design, of which the success rate can reach 75.9%. As compared with other studies employing the sequence space Monte Carlo technique, this method is more speedy and effective, and saves the time, to great extent, of searching sequence space, which can be seen as the simplification and improvement of the previous works of the same kind.
【Fund】: 国家自然科学基金资助项目(10174005);; 北京市自然科学基金资助项目(5032002).
【CateGory Index】: O629
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 Lu Benzhuo a, Wang Cunxin b** , Wang Baohan c (a. Department of Astronomy and Applied Physics, University of Science and Technology of China, Hefei 230026; b. College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100022; c. Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101);A New Minimization Method for Real Protein Folding Prediction[J];Chinese Journal of Chemical Physics;2003-02
【Co-citations】
Chinese Journal Full-text Database 4 Hits
1 QI LiSheng1, SU JiGuo1,2, CHEN WeiZu1 & WANG CunXin1 1 College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, China; 2 College of Science, Yanshan University, Qinhuangdao 066004, China;Improvement of the relative entropy based protein folding method[J];中国科学(G辑:物理学 力学 天文学)(英文版);2009-06
2 LIU Yun 1) ,WANG Cun Xin 1)** ,WANG Bao Han 2) ,CHEN Wei Zu 1) ( 1) College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100022, China; 2) Institute of Biophysics, The Academy Sciences of China, Beijing 100101, China);A Protein Design Procedure Based on The Lattice Model[J];Progress In Biochemistry and Biophysics;2004-02
3 QI Li-Sheng1), SU Ji-Guo1, 2), CHEN Wei-Zu1), WANG Cun-Xin1) (1)College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, China; 2)College of Science, Yanshan University, Qinhuangdao 066004, China);Application of Protein Design Method Based on The HNP Model and Relative Entropy for Different Protein Systems[J];Progress in Biochemistry and Biophysics;2008-09
4 LIU Yun1, WANG Yi-hua1, WANG Bao-han2, WANG Cun-xin1, CHEN Wei-zu1(1. College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100022, China; 2. Institute of Biophysics, The Chinese Academy of Sciences, Beijing 100101, China);AN APPROACH TO DESIGN PROTEINS OF FOUR STRUCTURAL CLASSES[J];Acta Biophysica Sinica;2004-04
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