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《Journal of Beijing University of Chemical Technology(Natural Science Edition)》 2013-01
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The effects of sterilization method on the protein adsorption capacity of TiO_2 nanotubes on the surface of titanium implants

SUN YanWei1 LU WuLong1 ZHANG ZhenTing2 WANG Na2 LI YanQiu1(1.Hospital of Stomatology,Tianjin Medical University,Tianjin 300070,China;2.Affiliated Hospital of Stomatology, Capital Medical University,Beijing 100050,China)  
The aim of this study was to compare the effects of ultraviolent irradiation and autoclaving on the wettability and protein adsorption of TiO2 nanotubes on the surface of titanium.Pure titanium sheets were polished with SiC abrasive paper.The polished titanium sheets were anodized under a voltage of 20V,which resulted in a nanotubular topography with a tube diameter of 80-100 nm on the surface of titanium(NT-Ti).The samples were then sterilized with UV irradiation or autoclaving.The results of contact angle measurements indicated that the contact angles of NT-Ti sterilized with UV irradiation were smaller than those of NT-Ti sterilized with autoclaving,showing that NT-Ti sterilized by UV irradiation was more hydrophilic than that sterilized by autoclaving.The adsorption behavior of bovine serum albumin(BSA) on the nanotube arrays was investigated at 37 ℃.The release experiment results suggested that protein adsorption on the UV irradiated materials was greater than that for the autoclaved materials,while protein release from the autoclaved materials was faster than that from the UV irradiated materials.Therefore it is recommended that such implants are sterilized by UV irradiation in the future.
【CateGory Index】: R783;TB383.1
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