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《Labeled Immunoassays and Clinical Medicine》 2016-12
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Correlation Between Appetite Hormone,Inflammatory Cytokines and Body Mass Index in Pulmonary Tuberculosis Patients with or Without Type 2 Diabetes Mellitus

QI Wei-qiang;LIU Chu;Shanghai Public Health Clinical Center;Hangzhou DIAN Medical Diagnosis Co.Ltd;  
Objective To investigate appetite related hormones and cytokines levels in pulmonary tuberculosispatients with or without type 2 diabetes mellitus and healthy people,and their relationship with BMI( body mass index). Methods We selected pulmonary tuberculosis patients without type 2 diabetes as study group A andpulmonary tuberculosis with type 2 diabetes patients as group B,and healthy people as control group,70 per group. All subjects were randomly selected during January 2014 to January 2016 in our hospital. The levels of blood Leptin,Ghrelin and IL-6 TNF-α and IFN-γ were detected,and the correlation between these factors and the BMI index was analyzed. Results( 1) BMI of the control group was higher than that of group A and B,and there was a significant difference between the control group and the group B.Blood glucose in group B was significantly higher than that in group A andcontrol group. The high density lipoprotein cholesterol,albumin and total protein in control group were significantly higher than those in group A and group B( P 0. 05).( 2) Appetite hormoneleptin level in group A was significantly higher than group B and control group. Hunger element level in control group was higher than group A and group B,and the difference wasstatistically significant. TNF-α in group B was significantly higher than that of a and the control group; IL-6 levels in three groups showed no difference; IFN-γ in control groupwas higher than group A and B. There wasa significant difference between control group and group A.( 3) Leptin levels ofgroup A and group Bwere negative correlation with BMI,while ghrelin levels had apositive correlation with BMI. Leptin of control group was positively related to BMI. Hunger hormone levels and BMI were negatively correlated. The three inflammatory factors of group A were positively correlated with BMI. TNF-α and IFN-γ of group B werenegatively correlated with BMI. The three inflammatory factors in the control group were negatively correlated with the BMI. Conclusion High levels of leptin and lowlevels of ghrelin may be related to the lowBMI of diabetes patients,which might be accounted for the malnutrition in these patients.Inflammatory factors are different depending on the severity of the disease.
【CateGory Index】: R521;R587.1
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