Anti-CCP and Anti-AKA Application Value in the Diagnosis of Rheumatoid Arthritis
YAO Chun-hong;DENG Jian-ping;Clinical Laboratory of Huangshi Aikang Hospital;
Objective To compare the diagnostic value of anti-CCP and anti-AKA in rheumatoid arthritis and to explore the early diagnosis of rheumatoid arthritis( RA). Methods The anti-CCP( ELISA) and anti-AKA( indirect immunofluorescence assay) were used in 85 patients with RA and 74 patients with non-RA. Results The sensitivity and specificity of anti-CCP for the diagnosis of RA were 75. 3% and 93. 2%. The sensitivity and specificity of anti-AKA were 89. 4% and 85. 1%. There was no significant difference on the sensitivity of between anti-AKA and anti-CCP( P 0. 05). On the specificity of anti-AKA,the difference was significant( P 0. 05). The difference on sensitivity of anti-CCP and ant AKA combined detection was statistically significant( P 0. 05). The specificity of anti-CCP and anti-AKA combined was statistically significant( P 0. 05). Anti-CCP antibodies were higher for positive predictive value,combined detection of both offered high negative predictive value. Youden index on combined detection of anti-CCP or anti-AKA was higher than tested. Anti-CCP and anti-AKA were detected in 58 cases,anti-CCP or AKA positive in 85 cases. The positive rate of anti-CCP or anti-AKA( 96. 5%) was significantly higher than that( 68. 2%).Conclusion Anti-CCP and anti-AKA have higer sensitivity and specificity for diagnosis of RA. Combined detection of anti-CCP and anti-AKA can be used as good diagnostic indicators for early RA patients and RF negative RA patients.
【CateGory Index】： R593.22